Rationally reduced libraries for combinatorial pathway optimization minimizing experimental effort

Rationally reduced libraries for combinatorial pathway optimization minimizing experimental effort.

Rational flux design in metabolic engineering approaches remains difficult since important pathway information is frequently not available. Therefore empirical methods are applied that randomly change absolute and relative pathway enzyme levels and subsequently screen for variants with improved performance. However, screening is often limited on the analytical side, generating a strong incentiv...

Considering Stochastic and Combinatorial Optimization

Here, issues connected with characteristic stochastic practices are considered. In the first part, the plausibility of covering the arrangements of an improvement issue on subjective subgraphs is studied. The impulse for this strategy is a state where an advancement issue must be settled as often as possible for discretionary illustrations. Then, a preprocessing stage is considered that would q...

Combinatorial surrobody libraries.

A unique type of combinatorial protein libraries has been constructed. These libraries are based on the pre-B cell receptor (pre-BCR). The pre-BCR is a protein that is produced during normal development of the antibody repertoire. Unlike that of canonical antibodies, the pre-BCR subunit is a trimer that is composed of an antibody heavy chain paired with two surrogate light chain (SLC) component...

Methods and Models for Combinatorial Optimization Heuristis for Combinatorial Optimization

In some cases, we may be able to find “efficient” exact algorithms to solve a COP: for example, the problem of finding the shortest paths on a graph, under some reasonable assumptions often met in practise, can be solved by the Dijkstra or Bellman-Ford algorithms, able to provide optimal solutions in running times according to a polynomial function (of small degree). For more complex problems, ...

Computer Algebra Libraries for Combinatorial Structures